Note that it says do not let Sin Reign in your Mortal Body . It cannot Reign in your Spirit which is Perfect . Your Body has not yet been Redeemed . It is Corruptible . If will one day put on incorruption . At that time, it will be immune from Sin .
But, at the moment, your Body is Mortal meaning it is subject to Death . So, you must Mortify the Lusts of the Flesh in order to preserve it. - Col 3:5
Yes, the Holy Spirit is the One who will change us from Corruptible to Incorruptible at the appearing of our Lord ( 1Co 15:52 ).
However, we now have the 'quickener' in us to make us alive today. He is the One who implements the Provisions of Grace in our Lives according to our Faith in God's Word .
Unless we Walk in the Spirit we will not experience the Power that He represents.
We Walk in the Spirit by calling into play the Word Of God - Hearing, Believing, Receiving and Doing it ( He Be Re Do) .
All things for Life and Godliness are ours ( 2Pe 1:3, ) but they are appropriated according to the Power that Works in us ( Eph 3:20 ).
We are not to be Sick, Weak or Poor . We are supposed to be Healthy, Strong and Prosperous . And we can be in the Holy Spirit and the Word .
When we truly honour and praise Christ Jesus as He deserves the Holy Spirit manifests in and through us as Sons Of God .