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And even as they did not like to retain God in their Knowledge, God gave them over to a reprobate Mind, to do those things which are not convenient; - Rom 1:28
The most telling characteristic of a person with Reprobate Mind is that they do not consider God in their Knowledge or Thinking.
This leads them do say and do things that are "not convenient".
"Not convenient" means "not normal", "not common-sensical", "not sane".
Being Filled with all Unrighteousness, Fornication, Wickedness, Covetousness, maliciousness; full of envy, murder, Debate, deceit, malignity; whisperers,
Backbiters, haters of God, despiteful, proud, boasters, inventors of Evil things, disobedient to parents,
Without Understanding, covenantbreakers, without natural Affection, implacable, unmerciful:
Who knowing the Judgment of God, that they which commit such things are Worthy of Death, not only do the same, but have Pleasure in them that do them. - Rom 1:29-32
From the above we see that their disconnection from God results in all manner of Sin. The extent of their Depravity is that they enjoy the fact that others participate in those Sins.
The reality is that the decision to deny God leads inexorably to a Reprobate Mind. Disconnection from the Knowledge of God has negative short-term, long-term and eternal Consequences.
Heb 11:6 says that a person cannot come to God without believing that He is . Psm 14:1 says that a person who denies God's existence is a Fool.
So, God does not have to do anything to a person for them to have a Reprobate Mind. They do it to themselves. It is an act of their will. God respects their decision and gives them over to their desire.
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